1,1-环丙基二羧酸二乙酯合成路线 （共 67 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; 16 h; Heating;
参考文献
Wender, Paul A.; Zhang, Lei
Organic Letters, 2000 , vol. 2, # 15 p. 2323 - 2325
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Merck Frosst Canada, Inc.
Patent: US5428033 A1, 1995 ;
US 5428033 A
反应条件
1: 74 percent / NaN3, Et3N*HCl / various solvent(s) / 18 h / 100 °C 2: 81 percent / H2 / 10percent Pd/C / ethanol / 2 h / 1603.2 Torr / Ambient temperature View Scheme
参考文献
Lindstrom, Kyle J.; Crooks, Stephen L.
Synthetic Communications, 1990 , vol. 20, # 15 p. 2335 - 2337
反应条件
ethylaluminum dichloride in hexane; 1,2-dichloro-ethane 74 h; Ambient temperature; Yield given;
参考文献
Beal, Richard B.; Dombroski, Mark A.; Snider, Barry B.
Journal of Organic Chemistry, 1986 , vol. 51, # 23 p. 4391 - 4399
反应条件
ethylaluminum dichloride in dichloromethane T=0°C;
参考文献
Bambal, Ramesh; Kemmitt, Raymond D. W.
Journal of the Chemical Society, Chemical Communications, 1988 , # 11 p. 734 - 735
参考文献
Daviaud,G.; Miginiac,P.
Tetrahedron Letters, 1972 , p. 997 - 1000
反应条件
Na2[Fe(CO)4] 1.)THF, 4h, 2.)I2/EtOH,overnight; Yield given. Multistep reaction;
参考文献
Tamblyn, William H.; Waltermire, Robert E.
Tetrahedron Letters, 1983 , vol. 24, # 28 p. 2803 - 2806
反应条件
1: 88 percent / LiAlH4 / tetrahydrofuran / 0 °C 2: thionyl chloride, pyridine / 1 h / 0 °C View Scheme
参考文献
Itoh, Osamu; Kohmura, Yoshiro; Ichikawa, Yasunori; Umezu, Makoto; Okita, Tsutomu; Ichikawa, Katsuhiko
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 1 p. 146 - 153
反应条件
Na2[Fe(CO)4]; acetic acid 1.)THF, 4h, 2.)overnight; Yield given. Multistep reaction;
参考文献
Tamblyn, William H.; Waltermire, Robert E.
Tetrahedron Letters, 1983 , vol. 24, # 28 p. 2803 - 2806
反应条件
1: sodium hydroxide / ethanol; water / 0 - 20 °C 2: thionyl chloride / 2 h / |Reflux 3: triethylamine / dichloromethane / 0 - 20 °C 4: sodium hydroxide / ethanol / 1 h / 65 °C View Scheme
参考文献
ZHEJIANG BETA PHARMA INCORPORATION; HU, Shaojing; WANG, Fei; XU, Zhiguo; WANG, Yanping; WANG, Yinxiang
Patent: WO2014/713 A1, 2014 ;
