1,1-环丙基二羧酸二乙酯合成路线 （共 67 条）
反应条件
1.1: NaOH; H2O / 48 h / 20 °C 2.1: SF4 / 3 h / 30 °C 2.2: 36 percent / NaHCO3; H2O / Heating View Scheme
参考文献
Dmowski, Wojciech; Wolniewicz, Adam
Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 141 - 146
反应条件
1: With sodium hydroxide 2: With hydrogenchloride in water
参考文献
Sun, Na-Bo; Jin, Jian-Zhong; Lei, Chao; He, Fang-Yue
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7820 - 7822
参考文献
Daviaud,G.; Miginiac,P.
Tetrahedron Letters, 1972 , p. 997 - 1000
反应条件
sodium ethanolate T=105°C; im Autoklaven;
参考文献
Dox; Yoder
Journal of the American Chemical Society, 1921 , vol. 43, p. 2098,2099
参考文献
Dox; Yoder
Journal of the American Chemical Society, 1921 , vol. 43, p. 2098,2099
反应条件
1: 71.6 percent / KOH / ethanol / 6 h / 25 °C 2: SF4 / 21 h / 60 °C View Scheme
参考文献
Hell; Finta; Dmowski; Faigl; Pustovit; Toke; Harmat
Journal of Fluorine Chemistry, 2000 , vol. 104, # 2 p. 297 - 301
反应条件
samarium diiodide; iron(III) tris(dibenzoylmethane); tert-butyl alcohol in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Imamoto, Tsuneo; Hatajima, Toshihiko; Yoshizawa, Takeshi
Tetrahedron Letters, 1994 , vol. 35, # 42 p. 7805 - 7808
反应条件
potassium hydroxide T=0 - 20°C; 2 h;
参考文献
ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew
Patent: WO2013/96771 A1, 2013 ;
Location in patent: Page/Page column 229 ;
反应条件
1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 18 h / 20 °C 2: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
LEO PHARMA A/S; NIELSEN, Simon Feldbæk; LARSEN, Jens Christian Højland
Patent: WO2013/92739 A1, 2013 ;
反应条件
1.1: Mg / tetrahydrofuran / 4 h / 0 - 20 °C 1.2: 50 percent Chromat. / Me2S; CuI / tetrahydrofuran; various solvent(s) / 20 h / -30 - 20 °C 2.1: 67 percent / aq. LiCl / dimethylsulfoxide / 6 h / 175 - 178 °C View Scheme
参考文献
Prowotorow; Wicha; Mikami
Synthesis, 2001 , # 1 p. 145 - 149
