(1R,2R)-反式-N-叔丁氧羰基-2-氨基环己醇合成路线 （共 3 条）
反应条件
1: 97.9 percent / pyridine; DMAP / 0 °C 2: 87 percent / NaN3 / dimethylformamide / 12 h / 65 - 70 °C 3: H2 / PtO2 / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Govindaraju; Gonnade, Rajesh G.; Bhadbhade, Mohan M.; Kumar, Vaijayanti A.; Ganesh, Krishna N.
Organic Letters, 2003 , vol. 5, # 17 p. 3013 - 3016
反应条件
Multi-step reaction with 2 steps 1: NaOMe / methanol / 0.5 h / 20 °C2: ethyl acetate
参考文献
Govindaraju; Gonnade, Rajesh G.; Bhadbhade, Mohan M.; Kumar, Vaijayanti A.; Ganesh, Krishna N. Organic Letters, 2003 , vol. 5, # 17 p. 3013 - 3016
反应条件
Multi-step reaction with 3 steps 1: DIPEA; MsCl / 1,2-dichloro-ethane / 83 °C2: NaH / tetrahydrofuran / 2 h / 25 °C3: Cs2CO3 / aq. methanol
参考文献
Benedetti; Norbedo Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10071 - 10074
