Boc-L-环丙基甘氨酸合成路线 （共 13 条）
反应条件
1: With ruthenium trichloride; sodium periodate; water in tetrachloromethane; acetonitrile T=20°C; 2: With silica gel; dimethyl sulfoxide in dichloromethane 0.5 h; Further stages.;
参考文献
Chen, Young K.; Lurain, Alice E.; Walsh, Patrick J.
Journal of the American Chemical Society, 2002 , vol. 124, # 41 p. 12225 - 12231
反应条件
thiothreitol; McIlvaine's buffer cont. EDTA; papain (from Carica papaya) in N,N-dimethyl-formamide; acetonitrile T=20°C; pH=6.2; 36 h; Enzymatic reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 9 p. 1071 - 1078
反应条件
1.1: 93 percent / Zn / acetic acid / 0.5 h / 20 - 30 °C 2.1: SOCl2 / methanol / 20 h / 20 °C 3.1: K2CO3; NH2OH*HCl / dioxane; H2O / 12 h / 20 °C 3.2: 18.5 g / 3-dimethylaminopropylamine / dioxane; H2O / 1 h / 20 °C 4.1: 43 percent / McIlvaine's buffer cont. EDTA; thiothreitol / papain (from Carica papaya) / acetonitrile; dimethylformamide / 36 h / 20 °C / pH 6.2 / Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 9 p. 1071 - 1078
反应条件
1.1: 74 percent / KMnO4; Na2CO3 / H2O / 50 h / 50 °C 2.1: 99 percent / NH2OH*HCl / H2O / 0.33 h / 45 °C 3.1: 93 percent / Zn / acetic acid / 0.5 h / 20 - 30 °C 4.1: SOCl2 / methanol / 20 h / 20 °C 5.1: K2CO3; NH2OH*HCl / dioxane; H2O / 12 h / 20 °C 5.2: 18.5 g / 3-dimethylaminopropylamine / dioxane; H2O / 1 h / 20 °C 6.1: 43 percent / McIlvaine's buffer cont. EDTA; thiothreitol / papain (from Carica papaya) / acetonitrile; dimethylformamide / 36 h / 20 °C / pH 6.2 / Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 9 p. 1071 - 1078
反应条件
1.1: SOCl2 / methanol / 20 h / 20 °C 2.1: K2CO3; NH2OH*HCl / dioxane; H2O / 12 h / 20 °C 2.2: 18.5 g / 3-dimethylaminopropylamine / dioxane; H2O / 1 h / 20 °C 3.1: 43 percent / McIlvaine's buffer cont. EDTA; thiothreitol / papain (from Carica papaya) / acetonitrile; dimethylformamide / 36 h / 20 °C / pH 6.2 / Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 9 p. 1071 - 1078
反应条件
1.1: K2CO3; NH2OH*HCl / dioxane; H2O / 12 h / 20 °C 1.2: 18.5 g / 3-dimethylaminopropylamine / dioxane; H2O / 1 h / 20 °C 2.1: 43 percent / McIlvaine's buffer cont. EDTA; thiothreitol / papain (from Carica papaya) / acetonitrile; dimethylformamide / 36 h / 20 °C / pH 6.2 / Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 9 p. 1071 - 1078
反应条件
1: DBU / CH2Cl2 / 0 - 20 °C 2: 43 percent / McIlvaine's buffer cont. EDTA; thiothreitol / papain (from Carica papaya) / acetonitrile; dimethylformamide / 36 h / 20 °C / pH 6.2 / Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 9 p. 1071 - 1078
反应条件
1: With sodium hydroxide in water T=20°C; pH=9.7 - 10.1; 21 h; 2: With sulfuric acid in water pH=2;
参考文献
Organic Process Research and Development, , vol. 16, # 3 p. 464 - 469
反应条件
1: n-BuLi / tetrahydrofuran / -78 - 20 °C 2: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 3: PPTS / ethanol / 6 h / 50 °C 4: CrO3, H2SO4 / 1 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 2 p. 237 - 240
反应条件
1: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 2: PPTS / ethanol / 6 h / 50 °C 3: CrO3, H2SO4 / 1 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 2 p. 237 - 240
