2,4-二氨基-6-氯嘧啶合成路线 （共 36 条）
参考文献
Roth et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 2864,2867
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Merck and Co.Inc.
Patent: US2584024 , 1948 ;
参考文献
Ban, Masakazu; Taguchi, Hiroaki; Katsushima, Takeo; Aoki, Shoichi; Watanabe, Akihiko
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 7 p. 1057 - 1067
反应条件
peracetic acid in ethanol; acetic acid 1.) 7 deg C, 70 min; 2.) RT, 3 h;
参考文献
Muller; Ramuz
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1445 - 1453
反应条件
peracetic acid in ethanol; Petroleum ether
参考文献
Hoffmann-La Roche Inc.
Patent: US4150132 A1, 1979 ;
反应条件
sodium hydroxide in ethanol; water
参考文献
Hoffmann-La Roche Inc.
Patent: US4220772 A1, 1980 ;
反应条件
benzyl alcohol beim Erwaermen des Reaktionsprodukts mit NaNO2 und wss. Essigsaeure;
参考文献
Roth et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 2864,2867
反应条件
sodium hydride 6 h; Reflux;
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Segers, Kenneth; Anne, Jozef; Herdewijn, Piet
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 702 - 714
参考文献
Merck and Co.Inc.
Patent: US2584024 , 1948 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether Suzuki cross-coupling reaction; 48 h; Heating;
参考文献
Cooke; Augier de Cremiers; Rotello; Tarbit; Vanderstraeten
Tetrahedron, 2001 , vol. 57, # 14 p. 2787 - 2789
反应条件
sodium hydroxide; dihydrogen peroxide; acetic acid in tetrahydrofuran
参考文献
The Upjohn Company
Patent: US3998827 A1, 1976 ;
