1: With hydrogen bromide in water T=50°C; 0.333333 h; 2: With sodium nitrite in water T=0 - 5°C; 0.166667 h; 3: With hydrogen bromide; copper(I) bromide in water 2 h; Reflux;
参考文献
Glaxo Group Limited
Patent: US2009/197871 A1, 2009 ;
Location in patent: Page/Page column 50-51 ;
US 20090197871 A1
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.583333 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78°C; 1 h;
3: With hydrogenchloride; water in tetrahydrofuran; hexane
T=-78 - 20°C;
