3-氰基-4-羟基苯甲酸甲酯合成路线 （共 15 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=90°C; 14 h;
参考文献
Exelixis, Inc.
Patent: US2010/249071 A1, 2010 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere 2: sodium hydroxide / methanol / 16 h / 20 °C View Scheme
参考文献
GLAXO GROUP LIMITED; BAILEY, James; KING, Nigel Paul; LIN, Xichen; REN, Feng; TAN, Kheng-Chuan; MAK, Sing Yeung
Patent: WO2011/72488 A1, 2011 ;
WO 2011/072488 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 2 h; Inert atmosphere;
参考文献
WO2009/158393 A1, ;
Page/Page column 109 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
US2012/184587 A1, ;
Page/Page column 33 ;
反应条件
NaH in ethyl acetate; N,N-dimethyl-formamide
参考文献
US5939439 A1, ;
US 5939439 A
