5-溴-3-甲基-2-吡啶甲腈合成路线 （共 10 条）
反应条件
in N,N-dimethyl-formamide 2 h; Reflux;
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
Location in patent: Paragraph 0176 ;
反应条件
in N,N-dimethyl-formamide T=120°C; 12 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/100715 A1, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/100715 A1
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; Diazotization; 1 h; 2: With copper Substitution; 0.5 h; Heating;
参考文献
Afonso, Adriano; Weinstein, Jay; Kelly, Joseph; Wolin, Ronald; Rosenblum, Stuart B.; Connolly, Michael; Guzi, Timothy; James, Linda; Carr, Donna; Patton, Robert; Bishop, W.Robert; Kirshmeier, Paul; Liu; Heimark; Chen; Nomeir
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1845 - 1855
反应条件
1.1: 57 percent / tetrabutylammonium nitrate; TFAA; t-butyl methyl ether / 60 h / 20 °C 2.1: 85 percent / Fe; CaCl2 / aq. ethanol / 18 h / 20 °C 3.1: NaNO2; 48 percent HBr / H2O / 1 h / 0 °C 3.2: 78 percent / Cu / 0.5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1845 - 1855
反应条件
1.1: 85 percent / Fe; CaCl2 / aq. ethanol / 18 h / 20 °C 2.1: NaNO2; 48 percent HBr / H2O / 1 h / 0 °C 2.2: 78 percent / Cu / 0.5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1845 - 1855
反应条件
1: N-bromosuccinmide; ammonium acetate / acetonitrile / 0.42 h / 20 °C / Cooling with ice 2: hydrogen bromide; bromine; sodium nitrite / water / 3 h / -15 °C 3: N,N-dimethyl-formamide / 2 h / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 4 p. 1682 - 1697
反应条件
1: hydrogen bromide; bromine; sodium nitrite / water / 3 h / -15 - 23 °C 2: N,N-dimethyl-formamide / 2 h / |Reflux View Scheme
反应条件
1: With sodium hydroxide; water T=80°C; 1.5 h; 2: in water pH=2 - 3; Acidic aqueous solution;
参考文献
WO2008/100715 A1, ;
Page/Page column 33-34 ;
WO 2008/100715 A1
反应条件
hydrogenchloride T=25 - 64°C;
参考文献
Amgen Inc.
Patent: US2006/199817 A1, 2006 ;
Location in patent: Page/Page column 27 ;
US 20060199817 A1
反应条件
1: water; sodium hydroxide / ethanol / 1.5 h / 80 °C 2: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 80 °C View Scheme
参考文献
Incyte Corporation; Huang, Taisheng; Feng, Hao; Kong, Lingquan; Wang, Anlai; Ye, Hai Fen
Patent: US2013/96144 A1, 2013 ;
