6-甲氧基-2-甲基-(9CI)-3-吡啶羧醛合成路线 （共 4 条）
反应条件
1: 3-bromo-6-methoxy-2-methyl-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78°C;
参考文献
Ward, Jarrod; Caprio, Vittorio
Heterocycles, 2009 , vol. 79, # C p. 791 - 804
反应条件
1: 97 percent / silver carbonate / CHCl3 / 40 h 2: 73 percent / 0.15 M aq. Na2HPO4, bromine 3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 20 min, 2.) hexane, THF, -78 deg C, 40 min View Scheme
参考文献
Gray; Konopski; Langlois
Synthetic Communications, 1994 , vol. 24, # 10 p. 1367 - 1379
反应条件
1: 73 percent / 0.15 M aq. Na2HPO4, bromine 2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 20 min, 2.) hexane, THF, -78 deg C, 40 min View Scheme
参考文献
Gray; Konopski; Langlois
Synthetic Communications, 1994 , vol. 24, # 10 p. 1367 - 1379
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol; water T=0 - 5°C;
参考文献
BRISTOL-MYERS SQUIBB PHARMA COMPANY
Patent: WO2005/51954 A2, 2005 ;
Location in patent: Page/Page column 40; 41 ;
WO 2005/051954 A2
