in methanol

in methanol

1: LDA / tetrahydrofuran; hexane / -78 - 20 °C 2: 1.) aq. H2O2, LiOH, 2.) NaNO2 / 1.) THF, RT, 1.5 h, 2.) THF, 30 min View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, from -78 deg C to RT 2: LDA / tetrahydrofuran; hexane / -78 - 20 °C 3: 1.) aq. H2O2, LiOH, 2.) NaNO2 / 1.) THF, RT, 1.5 h, 2.) THF, 30 min View Scheme