(αr)-α-[[(1,1-二甲基乙氧基)羰基]氨基]-苯戊酸合成路线 （共 3 条）
反应条件
1.1: sodium ethoxide / ethanol / 1.5 h / 20 °C 1.2: 98 percent / ethanol / 16 h / Heating 2.1: NaOH / 3 h / 100 °C 3.1: 68.9 g / CoCl2; KCl; KOH / acylase I from Aspergillus melleus / H2O / 24 h / 40 °C / pH 8.0 4.1: 96 percent / hydrochloric acid / ethanol / 22 h / 85 °C 5.1: triethylamine / tetrahydrofuran / 18 h / 20 °C 6.1: 7.30 g / NaOH / 5 h / 60 °C View Scheme
参考文献
Evers, Britta; Ruehter, Gerd; Berg, Martina; Dodge, Jeffrey A.; Hankotius, Dirk; Hary, Ulrike; Jungheim, Louis N.; Mest, Hans-Juergen; De La Nava, Eva-Maria Martin; Mohr, Michael; Muehl, Brian S.; Petersen, Soenke; Sommer, Birgit; Riedel-Herold, Grit; Tebbe, Mark J.; Thrasher, Kenneth J.; Voelkers, Silke
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6748 - 6762
反应条件
1: 68.9 g / CoCl2; KCl; KOH / acylase I from Aspergillus melleus / H2O / 24 h / 40 °C / pH 8.0 2: 96 percent / hydrochloric acid / ethanol / 22 h / 85 °C 3: triethylamine / tetrahydrofuran / 18 h / 20 °C 4: 7.30 g / NaOH / 5 h / 60 °C View Scheme
参考文献
Evers, Britta; Ruehter, Gerd; Berg, Martina; Dodge, Jeffrey A.; Hankotius, Dirk; Hary, Ulrike; Jungheim, Louis N.; Mest, Hans-Juergen; De La Nava, Eva-Maria Martin; Mohr, Michael; Muehl, Brian S.; Petersen, Soenke; Sommer, Birgit; Riedel-Herold, Grit; Tebbe, Mark J.; Thrasher, Kenneth J.; Voelkers, Silke
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6748 - 6762
反应条件
1: NaOH / 3 h / 100 °C 2: 68.9 g / CoCl2; KCl; KOH / acylase I from Aspergillus melleus / H2O / 24 h / 40 °C / pH 8.0 3: 96 percent / hydrochloric acid / ethanol / 22 h / 85 °C 4: triethylamine / tetrahydrofuran / 18 h / 20 °C 5: 7.30 g / NaOH / 5 h / 60 °C View Scheme
参考文献
Evers, Britta; Ruehter, Gerd; Berg, Martina; Dodge, Jeffrey A.; Hankotius, Dirk; Hary, Ulrike; Jungheim, Louis N.; Mest, Hans-Juergen; De La Nava, Eva-Maria Martin; Mohr, Michael; Muehl, Brian S.; Petersen, Soenke; Sommer, Birgit; Riedel-Herold, Grit; Tebbe, Mark J.; Thrasher, Kenneth J.; Voelkers, Silke
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6748 - 6762
