1H-吡咯并[2,3-b]吡啶-3-甲酸合成路线 （共 11 条）
反应条件
1: With 1-hydroxy-pyrrolidine-2,5-dione; o-iodoxybenzoic acid in dimethyl sulfoxide T=20°C; 16 h; 2: With hydrogenchloride; water; sodium chloride in dimethyl sulfoxide pH=3 - 4;
参考文献
SCHWARZ PHARMA AG
Patent: WO2006/50976 A1, 2006 ;
Location in patent: Page/Page column 31 ;
WO 2006/050976 A1
反应条件
1: With potassium hydroxide in water 2 h; 2: With hydrogenchloride in water pH=2;
参考文献
WO2008/5457 A2, ;
Page/Page column 73 ;
WO 2008/005457 A2
反应条件
hydrogenchloride T=70°C;
参考文献
Chinese Chemical Letters, , vol. 22, # 3 p. 272 - 275
反应条件
1: toluene-4-sulfonic acid / toluene / 95 °C 2: AlCl3, aluminium chloride / anhydrous xylene / 8 h / Reflux 3: hydrogenchloride / 70 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 3 p. 272 - 275
反应条件
1: potassium hydroxide / ethanol 2: toluene-4-sulfonic acid / toluene / 95 °C 3: AlCl3, aluminium chloride / anhydrous xylene / 8 h / Reflux 4: hydrogenchloride / 70 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 3 p. 272 - 275
反应条件
1: AlCl3, aluminium chloride / chlorobenzene / 8 h / |Reflux; |Inert atmosphere; |Large scale 2: hydrogenchloride; water / 20 h / 70 °C / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 2 p. 209 - 213
反应条件
Erhitzen des Reaktionsprodukts mit wss.HCl;
参考文献
Journal of the American Chemical Society, , vol. 78, p. 1247,1249
反应条件
1: With AlCl3, aluminium chloride 2: With potassium hydroxide 3: With hydrogenchloride
参考文献
Organic Process Research and Development, , vol. 7, # 2 p. 209 - 213
反应条件
sodium; 1-methyl-naphthalene Behandeln des Reaktionsgemisches mit CO2;
参考文献
Chemische Berichte, , vol. 76, p. 128,134
反应条件
sulfuric acid in methanol T=20°C; 16 h; Heating / reflux;
参考文献
AVENTIS PHARMA DEUTSCHLAND GMBH
Patent: WO2004/111048 A1, 2004 ;
Location in patent: Page 40 ;
