1: 79 percent / MeONa / methanol / 1 h / Ambient temperature 2: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme

sodium methylate in methanol 1 h; Ambient temperature;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1737614', constants.ctx, '0')">N,N-dimethyl acetamide</a> <br />20&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 23 percent / p-TsOH / 0.83 h / 160 &deg;C / 25 Torr<br />2: 75 percent / NaN₃ / ethanol; H₂O / 1.) reflux, 1 h, 2.) room temperature, 20 h<br />3: 94 percent / H₂ / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 75 percent / NaN₃ / ethanol; H₂O / 1.) reflux, 1 h, 2.) room temperature, 20 h<br />2: 94 percent / H₂ / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature<br /> <br /> &nbsp;