1: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 2: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 3: 79 percent / MeONa / methanol / 1 h / Ambient temperature 4: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme

1: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 2: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 3: 79 percent / MeONa / methanol / 1 h / Ambient temperature View Scheme