2,2,3,3-四甲基环丙甲酸合成路线 （共 17 条）
反应条件
oxalyl dichloride in dichloromethane T=20°C; 0.8 h;
参考文献
Artman, Linda D.; Balandrin, Manuel F.; Moe, Scott T.; Van Wagenen, Bradford C.; Pesyan, Amir
Patent: US2006/25477 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
tetrabutylammomium bromide; potassium carbonate in hexane; water; toluene
参考文献
Shell Oil Company
Patent: US4061664 A1, 1977 ;
反应条件
1: SOCl2, DMF / CHCl3 / 1.58 h / 60 - 65 °C 2: pyridine / CH2Cl2 / 0.5 h View Scheme
参考文献
Wengatz, Ingrid; Stoutamire, Donald W.; Gee, Shirley J.; Hammock, Bruce D.
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 6 p. 2211 - 2221
参考文献
Furuhata, Akimichi; Matsui, Masanao
Agricultural and Biological Chemistry, 1987 , vol. 51, # 4 p. 1185 - 1188
反应条件
sulfuric acid
Heating / reflux;
参考文献
Pessah, Neta; Bialer, Meir; Wlodarczyk, Bogdan; Finnell, Richard H.; Yagen, Boris
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2233 - 2242
反应条件
thionyl chloride; ammonia in N,N-dimethyl acetamide
T=-5 - 20°C;
参考文献
Wang, Hui-Long; Jiang, Wen-Feng; Li, Zhe-Qi
Journal of Chemical Research, 2009 , # 8 p. 508 - 510
反应条件
in tetrahydrofuran; diethyl ether
T=-5°C; Condensation; 2 h;
参考文献
Thamattoor, Dasan M.; Snoonian, John R.; Sulzbach, Horst M.; Hadad, Christopher M.
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 5886 - 5895
