2,8-二甲基-4-羟基喹啉合成路线 （共 10 条）
反应条件
calcium sulfate T=95 - 100°C; Erhitzen des Reaktionsprodukts in Biphenyl und Diphenylaether auf 250grad-260grad;
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2402
反应条件
1: aq. HCl / 20 °C 2: diphenyl ether / 240 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 42, # 9 p. 2069 - 2073
反应条件
T=20°C; beim Erhitzen des erhaltenen β-o-Tolylimino-buttersaeure-aethylester auf 240grad bis 250grad;
参考文献
DE42276 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 204
Chemische Berichte, , vol. 21, p. 525
反应条件
in diphenylether 0.5 h; Reflux;
参考文献
Medicinal Chemistry Research, , vol. 21, # 10 p. 3073 - 3079,7
反应条件
trichlorophosphate Vilsmeier-Haack reaction; 12.5 h; Heating;
参考文献
Journal of the Indian Chemical Society, , vol. 81, # 7 p. 598 - 601
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0 - 5°C; 1.5 h; 2: 8-methyl-4-hydroxyquinaldine T=100°C; Vilsmeier-Haack reaction; 12.5 h;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 42, # 9 p. 2069 - 2073
反应条件
trichlorophosphate T=75°C;
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
1: trichlorophosphate / 3 h / |Reflux
2: hydrazine hydrate / |Reflux
View Scheme
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0 - 5°C; 1.5 h;
2: 8-methyl-4-hydroxyquinaldine T=100°C; Vilsmeier-Haack reaction; 12.5 h;
参考文献
Kumar, R. Nandha; Suresh; Dhanabal; Mohan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 4 p. 846 - 851
