(2R,3R)-3-[(t-丁氧羰基)氨基]-4-苯基-1,2-环氧丁烷合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol 2 h;
参考文献
GILEAD SCIENCES, INC.,
Patent: WO2008/13834 A1, 2008 ;
Location in patent: Page/Page column 35; 36 ;
WO 2008/013834 A1
反应条件
1.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / -15 °C 1.2: tetrahydrofuran / 2 h / 0 °C 1.3: aq. HBr / tetrahydrofuran 2.1: (S)-2-methyl-CBS-oxazaborolidine; boranemethyl sulfide / toluene; tetrahydrofuran / 1 h / 20 °C 3.1: NaOMe / methanol / 1.5 h View Scheme
参考文献
Bakshi, Pancham; Wolfe, Michael S.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6485 - 6489
反应条件
Oxonereg;; ammonium acetate; ammonium hydrogen carbonate; lt;meso-tetrakis(2,6-dichlorophenyl)porphyrinatogt;manganese(III) chloride in water; acetonitrile T=20°C; 1 h; Product distribution / selectivity;
参考文献
Che, Chi-Ming; Wong, Man-Kin
Patent: US2005/209470 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1.1: thionyl chloride / 5 h / Reflux 2.1: sodium hydrogencarbonate / 16 h / 20 °C 3.1: methyl-magnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere 3.2: 2.75 h / 10 °C / Reflux 4.1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux 5.1: sodium hydroxide / acetone / 1.5 h / 20 °C View Scheme
参考文献
Babu, Kilaru Ravendra; Rao, Valasani Koteswara; Sudhakar, Yellapu; Raju, Chamarthi Naga
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 6 p. 849 - 854
反应条件
1.1: sodium hydrogencarbonate / 16 h / 20 °C 2.1: methyl-magnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere 2.2: 2.75 h / 10 °C / Reflux 3.1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux 4.1: sodium hydroxide / acetone / 1.5 h / 20 °C View Scheme
参考文献
Babu, Kilaru Ravendra; Rao, Valasani Koteswara; Sudhakar, Yellapu; Raju, Chamarthi Naga
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 6 p. 849 - 854
反应条件
1.1: methyl-magnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere 1.2: 2.75 h / 10 °C / Reflux 2.1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux 3.1: sodium hydroxide / acetone / 1.5 h / 20 °C View Scheme
参考文献
Babu, Kilaru Ravendra; Rao, Valasani Koteswara; Sudhakar, Yellapu; Raju, Chamarthi Naga
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 6 p. 849 - 854
反应条件
1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux 2: sodium hydroxide / acetone / 1.5 h / 20 °C View Scheme
参考文献
Babu, Kilaru Ravendra; Rao, Valasani Koteswara; Sudhakar, Yellapu; Raju, Chamarthi Naga
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 6 p. 849 - 854
