1: 1-bromo-4-butoxy-3-fluorobenzene With n-butyllithium in tetrahydrofuran T=-70°C; 2 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran T=-70 - 20°C; 16 h; 3: With water; hydrogenchloride in tetrahydrofuran

1.1: sodium hydroxide / tetrabutylammomium bromide / water / 6 h / 80 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere 2.2: 16 h / -70 - 20 °C View Scheme