反应条件
1: 6-chloro-9H-purin-2-ylamine With 3,4-dihydro-2H-pyran; hydrogenchloride in diethyl ether; N,N-dimethyl-formamide T=60°C; 2: dihydroxy-thien-2-ylborane With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Suzuki coupling; Heating; 3: With Amberlyst in methanol Heating; Further stages.;
参考文献
Gillespie, Roger J.; Cliffe, Ian A.; Dawson, Claire E.; Dourish, Colin T.; Gaur, Suneel; Jordan, Allan M.; Knight, Antony R.; Lerpiniere, Joanne; Misra, Anil; Pratt, Robert M.; Roffey, Jonathan; Stratton, Gemma C.; Upton, Rebecca; Weiss, Scott M.; Williamson, Douglas S.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 9 p. 2924 - 2929
