3-(甲基硫代)-6-苯基-1,2,4-噻嗪-5(2H)-酮合成路线 （共 14 条）
反应条件
1: thiosemicarbazide; α-ketophenylacetic acid in water 0.25 h; Heating / reflux; 2: With potassium hydroxide in methanol; water T=80°C; 48 h; 3: methyl iodide in methanol; water T=40°C; 0.5 h;
参考文献
INCYTE CORPORATION
Patent: US2008/39457 A1, 2008 ;
Location in patent: Page/Page column 31 ;
US 20080039457 A1
反应条件
1: 3-mercapto-6-phenyl-1,2-4-triazin-5(4H)-one With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
AVENTIS PHARMA S.A.
Patent: US2008/96891 A1, 2008 ;
Location in patent: Page/Page column 5-6 ;
反应条件
sodium hydroxide in methanol; water T=20 - 25°C; 3.5 h;
参考文献
Mironovich, L. M.; Salistyi, S. M.
Russian Journal of Applied Chemistry, 1994 , vol. 67, # 6.2 p. 888 - 890
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1994 , vol. 67, # 6 p. 998 - 1001
反应条件
ethanol; acetic acid
参考文献
Wellcome Found.
Patent: DE951996 , 1953 ;
Full Text Show Details
Hagenbach et al.
Angewandte Chemie, 1954 , vol. 66, p. 359,361
反应条件
n-butyllithium; O-(2,4-dinitro-phenyl)-hydroxylamine in tetrahydrofuran
Ambient temperature;
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1583 - 1584
反应条件
1: 62 percent / O-(2,4-dinitrophenyl)-hydroxylamine, n-butyllithium / tetrahydrofuran / Ambient temperature
2: 63 percent / NaOH; acetic acid / 1 h / Heating
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
反应条件
1: 62 percent / O-(2,4-dinitrophenyl)-hydroxylamine, n-butyllithium / tetrahydrofuran / Ambient temperature
2: 63 percent / NaOH; acetic acid / 1 h / Heating
3: 89 percent / diethyl ether
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
反应条件
1: 1.) n-butyllithium, 2.) O-(2,4-dinitrophenyl)hydroxylamine / 1.) THF, hexane, -35 deg C, 10 min, 2.) -10 deg C, 15 min; R.T., 24 h.
2: 77 percent / 18percent ammonium hydroxide / pyridine / 3 h / 100 °C / sealed tube
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
反应条件
1: 1.) n-butyllithium, 2.) O-(2,4-dinitrophenyl)hydroxylamine / 1.) THF, hexane, -35 deg C, 10 min, 2.) -10 deg C, 15 min; R.T., 24 h.
2: 70 percent / pyridine / 3 h / 100 °C / sealed tube
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
反应条件
1: 1.) n-butyllithium, 2.) O-(2,4-dinitrophenyl)hydroxylamine / 1.) THF, hexane, -35 deg C, 10 min, 2.) -10 deg C, 15 min; R.T., 24 h.
2: 77 percent / 18percent ammonium hydroxide / pyridine / 3 h / 100 °C / sealed tube
3: 78 percent / 4 h / Heating
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
