3-(甲基硫代)-6-苯基-1,2,4-噻嗪-5(2H)-酮合成路线 （共 14 条）
反应条件
1: 1.) n-butyllithium, 2.) O-(2,4-dinitrophenyl)hydroxylamine / 1.) THF, hexane, -35 deg C, 10 min, 2.) -10 deg C, 15 min; R.T., 24 h.
2: 70 percent / pyridine / 3 h / 100 °C / sealed tube
3: 93 percent / 4 h / Heating
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
反应条件
1: 1.) n-butyllithium, 2.) O-(2,4-dinitrophenyl)hydroxylamine / 1.) THF, hexane, -35 deg C, 10 min, 2.) -10 deg C, 15 min; R.T., 24 h.
2: 77 percent / 18percent ammonium hydroxide / pyridine / 3 h / 100 °C / sealed tube
3: 85 percent / 4 h / Heating
View Scheme
参考文献
Sanemitsu, Yuzuru; Nakayama, Yoshinori; Shiroshita, Masao
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1671 - 1675
反应条件
T=160 - 180°C; 1.5 h;
参考文献
Abdel-Hady, Sayed A. L.; Badawy, Mohamed A.; Ibrahim, Yehia A.; Pfleiderer, Wolfgang
Chemische Berichte, 1984 , vol. 117, # 3 p. 1077 - 1082
反应条件
hydrazine hydrate in isopropyl alcohol
5 h; Heating;
参考文献
Sasaki, Tadashi; Ito, Eikoh
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1353 - 1356
