6-溴-3,4-二氢-4-苯基-2H-1-苯并吡喃-2-酮合成路线 （共 12 条）
反应条件
1.1: potassium carbonate; sodium iodide / acetone / Reflux
2.1: sodium tetrahydroborate / ethylene glycol dimethyl ether / 0.17 h
2.2: 3 h / 10 °C
3.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
4.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
5.1: isopropyl alcohol / 15 h / 25 - 86 °C
6.1: sodium hydroxide / water
View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; VERMA, Shyam Sunder; HANDIQUE, Sourav; AHUJA, Seema; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/46135 A1, 2013 ;
反应条件
1: potassium carbonate / 60 - 65 °C
2: sodium hydroxide / water / 45 - 50 °C
3: ethanol / 5.83 h / 0 - 75 °C
4: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6: toluene / 1 h / 0 - 35 °C
7: tetrahydrofuran / 4.5 h / 60 - 65 °C
View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; VERMA, Shyam Sunder; HANDIQUE, Sourav; AHUJA, Seema; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/46135 A1, 2013 ;
