(±)-5-溴-b-苯基-2-(苯基甲氧基)-苯丙酸甲酯合成路线 （共 12 条）
反应条件
1.1: sodium tetrahydroborate / ethylene glycol dimethyl ether / 0.17 h
1.2: 3 h / 10 °C
2.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
3.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
4.1: isopropyl alcohol / 15 h / 25 - 86 °C
5.1: sodium hydroxide / water
View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; VERMA, Shyam Sunder; HANDIQUE, Sourav; AHUJA, Seema; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/46135 A1, 2013 ;
反应条件
1: sodium hydroxide / water / 45 - 50 °C
2: ethanol / 5.83 h / 0 - 75 °C
3: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
4: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
5: toluene / 1 h / 0 - 35 °C
6: tetrahydrofuran / 4.5 h / 60 - 65 °C
View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; VERMA, Shyam Sunder; HANDIQUE, Sourav; AHUJA, Seema; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/46135 A1, 2013 ;
