3-[(1R)-3-[二(异丙基)氨基]-1-苯基丙基]-4-苄氧基苯甲醇合成路线 （共 3 条）
反应条件
hydrogen; 5 Pd(II)/C(eggshell) in methanol T=50 - 55°C;
参考文献
ACTAVIS GROUP PTC EHF
Patent: US2010/217034 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
1.1: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 50 - 55 °C 2.1: dichloromethane / 1.5 h / 0 - 5 °C 2.2: 1 h / 0 - 5 °C View Scheme
反应条件
Stage #1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=30 - 55°C; Stage #2: With water; sodium hydroxide in toluene T=0 - 5°C; 0.333333 h; Show Experimental Procedure
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; REGURI, Buchi, Reddy; UPPARAPALLI, Sampath, Kumar; SAHU, Nilam; KRISHNASAMY, Mariappan; GNANI PEER MOHAMED, Syed, Ibrahim; SWAMINATHAN, Susi Patent: WO2011/145019 A1, 2011 ; Location in patent: Page/Page column 24 ;
