反应条件
1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C
2: triethylamine / dichloromethane / 0 °C
3: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C
4: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C
5: ethanol / 3 h / 80 °C / |Sealed tube
6: |Resolution of racemate
View Scheme
参考文献
Meredith, Erik L.; Ksander, Gary; Monovich, Lauren G.; Papillon, Julien P. N.; Liu, Qian; Miranda, Karl; Morris, Patrick; Rao, Chang; Burgis, Robin; Capparelli, Michael; Hu, Qi-Ying; Singh, Alok; Rigel, Dean F.; Jeng, Arco Y.; Beil, Michael; Fu, Fumin; Hu, Chii-Whei; Lasala, Daniel
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 12 p. 1203 - 1207