3-(2-噻吩基)丙烯酸合成路线 （共 20 条）
反应条件
potassium acetate; silicon tetraacetate T=170°C;
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 1554,1556; engl. Ausg. S. 1603
反应条件
methanol; sodium hydroxide T=20°C; 0.333333 h;
参考文献
Tetrahedron Letters, , vol. 32, # 40 p. 5625 - 5628
反应条件
phenylalanine ammonia-lyase in various solvent(s) T=30°C; pH=8.8; Enzyme kinetics;
参考文献
Chemistry - A European Journal, , vol. 12, # 10 p. 2739 - 2744
反应条件
hydrogen; palladium on activated charcoal in methanol T=50°C; P=2585.7 Torr;
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1.1: 10 Pd/C; hydrogen / 12 h / 70 °C / 4500.45 Torr 2.1: sodium hydroxide / water; tetrahydrofuran / 3 h / |Reflux 2.2: 20 °C 3.1: polyphosphoric acid / chlorobenzene / 0.38 h / 130 °C / |Inert atmosphere View Scheme
参考文献
MacHara, Ales; Svoboda, Jiri
Chemical Papers, 2013 , vol. 67, # 1 p. 59 - 65,7
反应条件
1: LiAlH4 2: MeLi View Scheme
参考文献
D'Auria, Maurizio; Ferri, Tomaso
Journal of Organic Chemistry, 1995 , vol. 60, # 26 p. 8360 - 8364
反应条件
1: With triethylamine in acetone Cooling with ice; 2: With sodium azide in water; acetone 1 h; Cooling with ice; 3: With tributyl-amine; diphenylamine T=220°C; 1.5 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
反应条件
T=170°C; Cyclization; 7 h;
参考文献
Lancelot, Jean-Charles; Letois, Bertrand; Saturnino, Carmela; Caprariis, Paolo De; Robba, Max
Organic Preparations and Procedures International, 1992 , vol. 24, # 2 p. 204 - 208
反应条件
10 Pd/C; hydrogen T=70°C; P=4500.45 Torr; 12 h;
参考文献
Chemical Papers, , vol. 67, # 1 p. 59 - 65,7
反应条件
trichlorophosphate
T=100°C; 4 h;
参考文献
Rose
Journal of Heterocyclic Chemistry, 1992 , vol. 28, # 8 p. 2005 - 2012
