(R)-吗啉-2-基甲醇盐酸盐合成路线 （共 8 条）
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene T=0 - 20°C; 17 h; 2: With potassium hydroxide; water in tetrahydrofuran; toluene T=0°C;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 263 ;
WO 2009/044162 A1
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=55 - 60°C; P=760 Torr; 4 h;
参考文献
Berg, Stefan; Larsson, Lars-Gunnar; Renyi, Lucy; Ross, Svante B.; Thorberg, Seth-Olof; Thorell-Svantesson, Gun
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1934 - 1942
反应条件
hydrogen; palladium on activated charcoal in methanol T=40°C; 30 h; Product distribution / selectivity;
参考文献
EP2388252 A1, ;
Page/Page column 13-14 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=50°C;
参考文献
Morie; Kato; Harada; Yoshida; Matsumoto
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 4 p. 877 - 882
反应条件
1: 97 percent / LAH / diethyl ether / 0.67 h / Ambient temperature 2: 52 percent / H2, conc. aq. HCl / 10percent Pd/C / ethanol / 4 h / 55 - 60 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1934 - 1942
反应条件
1: Na, MeOH / 4 h / Heating 2: 97 percent / LAH / diethyl ether / 0.67 h / Ambient temperature 3: 52 percent / H2, conc. aq. HCl / 10percent Pd/C / ethanol / 4 h / 55 - 60 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1934 - 1942
反应条件
triethylamine in dichloromethane T=20°C; 16 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 263-264 ;
WO 2009/044162 A1
反应条件
(R)-hexahydro-1,4-oxazepin-6-ol in methanol T=0 - 25°C;
参考文献
Daiso Co., Ltd.
Patent: EP2388252 A1, 2011 ;
Location in patent: Page/Page column 13-14 ;
