(3R,3AS,6AR)-六氢呋喃并[2,3-B]呋喃-3-醇合成路线 （共 53 条）
反应条件
1: With di-isopropyl azodicarboxylate; triphenylphosphine; 4-nitro-benzoic acid in benzene T=23°C; Mitsunobu reaction; 1.5 h; 2: With lithium hydroxide; triethylamine in methanol; water T=20°C; 2 h;
参考文献
WO2004/33462 A2, ;
Page 40; 41 ;
反应条件
1: With ozone 2: With toluene-4-sulfonic acid
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 4 p. 298 - 302
反应条件
sodium tetrahydroborate in ethanol T=-15 - 20°C; 3 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 17 p. 2015 - 2019
反应条件
1: With hydrogenchloride in tetrahydrofuran; water T=20°C; 23 h; 2: With potassium carbonate in tetrahydrofuran; water 0.333333 h;
参考文献
EP2634180 A1, ;
Paragraph 0104 ;
反应条件
methanol; potassium carbonate T=20°C; Product distribution / selectivity;
参考文献
WO2008/34598 A1, ;
Page/Page column 27 ;
反应条件
1: triethylamine / N,N-dimethylaminopyridine 2: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 3: potassium carbonate; methanol / 25 - 35 °C View Scheme
反应条件
1: With lithium borohydride in tetrahydrofuran T=50°C; 2.5 h; 2: With hydrogenchloride in tetrahydrofuran T=-10°C; 2 h;
参考文献
Organic Letters, , vol. 7, # 26 p. 5917 - 5920
反应条件
in ethylene glycol dimethyl ether T=23°C; immobilized Amano lipase;
参考文献
Journal of medicinal chemistry, , vol. 39, # 17 p. 3278 - 3290
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C;
参考文献
Tetrahedron Letters, , vol. 42, # 28 p. 4653 - 4656
反应条件
methanol; water; sodium hydroxide in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 19 p. 2394 - 2398
