(3R,3AS,6AR)-六氢呋喃并[2,3-B]呋喃-3-醇合成路线 （共 53 条）
反应条件
1: With sodium tetrahydroborate in methanol; isopropyl alcohol T=0°C; 1.5 h; 2: With ammonium chloride in methanol; isopropyl alcohol Product distribution / selectivity;
参考文献
WO2006/132390 A1, ;
Page/Page column 35-37 ;
反应条件
1: triethylamine 2: lithium aluminium tetrahydride / tetrahydrofuran 3: ozone View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 4 p. 298 - 302
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran 2: ozone View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 4 p. 298 - 302
反应条件
1.1: ethanol; sodium tetrahydroborate / 8 h / 15 - 60 °C / Inert atmosphere 1.2: 3 h / -10 - 0 °C 2.1: triethylamine / N,N-dimethylaminopyridine 3.1: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 4.1: potassium carbonate; methanol / 25 - 35 °C View Scheme
反应条件
1: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 2: potassium carbonate; methanol / 25 - 35 °C View Scheme
反应条件
1: Reduced nicotinamide-adenine dinucleotide; NADPH; aldo-ketoreductase KRED-243 / aq. phosphate buffer / 26 h / 30 °C / pH 7 / |Enzymatic reaction 2: diisobutylaluminium hydride 3: palladium 10 on activated carbon; hydrogen; formic acid / 10 h / 20 °C / 1500.15 Torr / |Inert atmosphere View Scheme
反应条件
Yb(hfc)3(+) T=50°C; 5 h; Product distribution / selectivity;
参考文献
WO2007/126812 A2, ;
Page/Page column 18-19 ;
反应条件
1: potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium hydrogencarbonate; tetrabutyl-ammonium chloride / dichloromethane; water / 1 h / 0 °C / |Inert atmosphere; |Large scale 2: sodium tetrahydroborate / dichloromethane; ethanol / 0 °C / |Inert atmosphere 3: acetic anhydride / ethylene glycol dimethyl ether / |Inert atmosphere; |Resolution of racemate; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 6 p. 972 - 980
反应条件
immobilized lipase PS-C1 in tert-butyl methyl ether 3 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Organic Process Research and Development, , vol. 15, # 1 p. 279 - 283
反应条件
1: sodium tetrahydroborate; methanol / 2 h / -5 - 0 °C 2: triethylamine / N,N-dimethylaminopyridine 3: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 4: potassium carbonate; methanol / 25 - 35 °C View Scheme
