(R)-α-甲氧基-2-萘乙酸合成路线 （共 14 条）
反应条件
1.1: 35 percent / nitrosylsulfuric acid / dimethylformamide / 24 h / 20 °C
2.1: SnBr2 / CH2Cl2 / 20 °C
2.2: 92 percent / CH2Cl2 / 20 °C
3.1: 45 percent / immobilized Burkholderia cepacia lipase; phosphate buffer; NaOH / decane; H2O / 38 h / 30 °C / pH 7.0
4.1: 75 percent / Rhodococcus rhodochrous IFO 15564; phosphate buffer / H2O; dimethylformamide; hexane / 24 h / 30 °C / pH 6.0
5.1: nitrosylsulfuric acid / dimethylformamide / 0.5 h / 0 °C
6.1: 13.0 mg / CH2Cl2
7.1: 48 percent / silica gel / diethyl ether
8.1: 100 percent / Krebsiella oxytoca esterase; phosphate buffer / H2O / 39 °C / pH 7.0
View Scheme
参考文献
Kimura, Mayumi; Kuboki, Atsuhito; Sugai, Takeshi
Tetrahedron Asymmetry, 2002 , vol. 13, # 10 p. 1059 - 1068
反应条件
1: nitrosylsulfuric acid / dimethylformamide / 0.5 h / 0 °C
2: 13.0 mg / CH2Cl2
3: 48 percent / silica gel / diethyl ether
4: 100 percent / Krebsiella oxytoca esterase; phosphate buffer / H2O / 39 °C / pH 7.0
View Scheme
参考文献
Kimura, Mayumi; Kuboki, Atsuhito; Sugai, Takeshi
Tetrahedron Asymmetry, 2002 , vol. 13, # 10 p. 1059 - 1068
反应条件
alkali
Yield given. Yields of byproduct given;
参考文献
Latypov, Sh. K.; Seco, J. M.; Quinoa, E.; Riguera, R.
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 504 - 515
参考文献
Kusumi, Takenori; Takahashi, Haruko; Xu, Ping; Fukusima, Toshiro; Asakawa, Yoshinori; et al.
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4397 - 4400
