2-氨基-5-溴-3-硝基三氟甲苯合成路线 （共 9 条）
反应条件
1: With nitric acid; sulfuric acid T=5 - 12°C; 2: With hydrogenchloride in methanol; water T=100°C;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 117-118 ;
反应条件
1: With hydrogenchloride in water T=110°C; 2: With sodium hydrogencarbonate in water pH=10;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 159 ;
反应条件
bromine; acetic acid T=20°C; 18 h;
参考文献
JANSSEN PHARMACEUTICA NV; PLAYER, Mark, R.; PARKS, Daniel, J.; PARSONS, William; MEEGALLA, Sanath, K; ILLIG, Carl, R.; BALLENTINE, Shelley, K.
Patent: WO2010/45166 A1, 2010 ;
Location in patent: Page/Page column 50 ;
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
water; potassium carbonate in methanol T=20°C; 4 h; Large scale reaction;
参考文献
Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 652 - 655
反应条件
1: With SnCl2·2H2O; ethanol in ethyl acetate T=70°C; 2 h; 2: With sodium hydrogencarbonate in water pH=10;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 159 ;
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
参考文献
Bayer Aktiengesellschaft
Patent: US5585395 A1, 1996 ;
