5-溴-3-(三氟甲基)苯-1,2-二胺合成路线 （共 8 条）
反应条件
1: With SnCl2·2H2O; ethanol in ethyl acetate T=70°C; 2 h; 2: With sodium hydrogencarbonate in water pH=10;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 159 ;
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating 4: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
1: concd. H2SO4, concd. HNO3 / 0 - 20 °C 2: concd. HCl / Heating 3: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
1: concd. HCl / Heating 2: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
