(S)-3-(Boc-氨基)-2,4-二甲基-2-戊醇合成路线 （共 9 条）
反应条件
in tetrahydrofuran Inert atmosphere;
参考文献
Podhajsky, Susanne M.; Iwai, Yasumasa; Cook-Sneathen, Amanda; Sigman, Matthew S.
Tetrahedron, 2011 , vol. 67, # 24 p. 4435 - 4441
反应条件
in tetrahydrofuran; diethyl ether T=20°C; 20 h;
参考文献
Gibson, Susan E.; Mainolfi, Nello; Kalindjian, S. Barret; Wright, Paul T.; White, Andrew J. P.
Chemistry - A European Journal, 2005 , vol. 11, # 1 p. 69 - 80
反应条件
1: 99 percent / NaHCO3 / methanol; tetrahydrofuran / 20 h / 20 °C 2: 76 percent / tetrahydrofuran; diethyl ether / 20 h / 20 °C View Scheme
参考文献
Campbell, Craig D.; Concellon, Carmen; Smith, Andrew D.
Tetrahedron Asymmetry, 2011 , vol. 22, # 7 p. 797 - 811
反应条件
in tetrahydrofuran 1.) 0 deg C, 2.) r.t., 20 h;
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Polywka, Mario E. C.; Shyam Prasad; Sanganee, Hitesh J.
Synlett, 1998 , # 5 p. 519 - 521
反应条件
1: 99 percent / NaHCO3 / methanol; tetrahydrofuran / 20 h / 20 °C 2: 76 percent / tetrahydrofuran; diethyl ether / 20 h / 20 °C View Scheme
参考文献
Podhajsky, Susanne M.; Iwai, Yasumasa; Cook-Sneathen, Amanda; Sigman, Matthew S.
Tetrahedron, 2011 , vol. 67, # 24 p. 4435 - 4441
反应条件
1.1: thionyl chloride / 0 - 20 °C 2.1: sodium hydrogencarbonate / ethanol / 48 h / 20 °C 3.1: tetrahydrofuran; diethyl ether / 0 - 20 °C 3.2: Cooling with ice View Scheme
参考文献
Belanger, Etienne; Pouliot, Marie-France; Courtemanche, Marc-Andre; Paquin, Jean-Francois
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 317 - 331
反应条件
hydrogenchloride in ethyl acetate T=20°C; 16 h;
参考文献
Gibson, Susan E.; Mainolfi, Nello; Kalindjian, S. Barret; Wright, Paul T.; White, Andrew J. P.
Chemistry - A European Journal, 2005 , vol. 11, # 1 p. 69 - 80
反应条件
1: hydrogenchloride; water / 1,4-dioxane / Inert atmosphere 2: triethylamine / 1,4-dioxane / 2 h / 0 °C / Inert atmosphere 3: methanesulfonic acid / dichloromethane / 0 - 20 °C / Inert atmosphere 4: potassium hydride / toluene / 20 - 120 °C / Inert atmosphere View Scheme
参考文献
Belanger, Etienne; Pouliot, Marie-France; Courtemanche, Marc-Andre; Paquin, Jean-Francois
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 317 - 331
反应条件
potassium tert-butylate in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Polywka, Mario E. C.; Shyam Prasad; Sanganee, Hitesh J.
Synlett, 1998 , # 5 p. 519 - 521
