(R)-1-苯基-2-丙醇合成路线 （共 57 条）
反应条件
Candida antarctica lipase B immobilized on acrylic resin in tetrahydrofuran; hexane T=25°C; P=750.075 Torr; Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 2 p. 237 - 246
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
1: methylmagnesium bromide With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in toluene T=-20°C; 0.166667 h; Inert atmosphere; 2: phenylacetaldehyde in toluene T=-40°C; Grignard reaction; 4 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 34 p. 6851 - 6855
反应条件
1: With (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol; titanium (IV) isopropoxide in toluene T=-40°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 20 p. 3732 - 3736
反应条件
lipase from candida antartica in aq. phosphate buffer T=30°C; 48 h;
参考文献
Kataoka, Noriyuki; Okudomi, Masayuki; Chihara, Naoka; Matsumoto, Kazutsugu
Letters in Organic Chemistry, 2012 , vol. 9, # 9 p. 615 - 621
反应条件
dihydrogen peroxide; sodium hydroxide in tetrahydrofuran T=0°C; 0.333333 h; Cooling with ice;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1685 - 1691
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.5 h / -30 °C 1.2: 68 percent / tetrahydrofuran / 1 h / 20 °C 2.1: Sphingomonas paucimobilis NCIMB 8195 / dimethylformamide; H2O; various solvent(s) / 120 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 19 p. 6495 - 6497
反应条件
lipase AK from Pseudomonas fluorescens in tetrahydrofuran; hexane T=30°C; 4 h; Sealed tube; optical yield given as percent ee;
参考文献
Process Biochemistry, , vol. 47, # 3 p. 428 - 434
反应条件
D-glucopyranose in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=8; 4 h; enantioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 12 p. 3120 - 3124
Angew. Chem., , vol. 126, # 12 p. 3348,1
反应条件
D-glucopyranose in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=8; 4 h; Reagent/catalyst; enantioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 12 p. 3120 - 3124
Angew. Chem., , vol. 126, # 12 p. 3348,1
