1: With n-butyllithium; 2-(dimethylamino)-ethanol in hexane T=0°C; 1 h; 2: With carbon tetrabromide in tetrahydrofuran; hexane T=-78°C; 1 h; Further stages.;

1.1: 2-(dimethylamino)ethanol; nBuLi / hexane / 1 h / 0 °C 1.2: 80 percent / C2Cl6 / hexane; tetrahydrofuran / 1 h / -78 °C 2.1: 2-(dimethylamino)ethanol; nBuLi / hexane / 1 h / 0 °C 2.2: 80 percent / CBr4 / hexane; tetrahydrofuran / 1 h / -78 °C View Scheme

sodium chloride in hexane; ethyl acetate; N,N-dimethyl-formamide