反应条件
1: NEt3 / CH2Cl2 / 0.17 h / 0 °C
2: 1.) caesium acetate, 2.) K2CO3, MeOH / 1.) DMF, 40-50 deg C, 24 h, 2.) 20 deg C, 1 h
3: 100 percent / H2, AcOH / Pd black / 18 h
View Scheme
参考文献
Le Merrer, Yves; Poitout, Lydie; Depezay, Jean-Claude; Dosbaa, Isabelle; Geoffroy, Sabine; Foglietti, Marie-Jose
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 519 - 533
