6-(4-氟苯基)吡啶-2-甲醛合成路线 （共 11 条）
反应条件
potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in tetrahydrofuran 18 h; Inert atmosphereReflux;
参考文献
Nareddy, Pradeep; Mantilli, Luca; Guenee, Laure; Mazet, Clement
Angewandte Chemie - International Edition, 2012 , vol. 51, # 16 p. 3826 - 3831
反应条件
1: n-butyllithium With 2-(dimethylamino)-ethanol in hexane 0.5 h; Inert atmosphereSchlenk technique; 2: p-di-pyridin-2-yl benzene in hexane T=0°C; 0.5 h; Inert atmosphereSchlenk technique; 3: N,N-dimethyl-formamide in hexane T=-78°C; 1 h; Inert atmosphereSchlenk technique;
参考文献
Journal of Organometallic Chemistry, , vol. 718, p. 8 - 13,6
反应条件
hexamethyl-distannane; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane 18 h; Heating;
参考文献
Zhang; Thomas; Wu
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1500 - 1502
反应条件
in tetrahydrofuran; hexane T=-78°C; 1.66667 h;
参考文献
EP1683804 A2, ;
Page/Page column 31 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; Stille cross-coupling; 48 h; Inert atmosphere;
参考文献
Journal of Organometallic Chemistry, , vol. 695, # 1 p. 103 - 110
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide T=25°C; 1.5 h;
参考文献
Iqbal, Nadeem; Akula, Murthy R.; Vo, Dean; Matowe, Wandikayi C.; McEwen, Carol-Anne; Wolowyk, Michael W.; Knaus, Edward E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1827 - 1837
反应条件
1: 60 percent / 35 percent aq. H2O2, glacial AcOH / 3 h / 70 - 80 °C 2: 75 percent / 1 h / Heating 3: 55 percent / 1 N NaOH / methanol / 1.5 h / 25 °C 4: 40 percent / H3PO4, DMSO, N,N'-dicyclohexylcarbodiimide / 1.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1827 - 1837
反应条件
1: 75 percent / 1 h / Heating 2: 55 percent / 1 N NaOH / methanol / 1.5 h / 25 °C 3: 40 percent / H3PO4, DMSO, N,N'-dicyclohexylcarbodiimide / 1.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1827 - 1837
反应条件
1: 55 percent / 1 N NaOH / methanol / 1.5 h / 25 °C 2: 40 percent / H3PO4, DMSO, N,N'-dicyclohexylcarbodiimide / 1.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1827 - 1837
反应条件
1: n-butyllithium / diethyl ether / -60 °C 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / Reflux View Scheme
参考文献
Dalton Transactions, , vol. 41, # 6 p. 1792 - 1800
