3,4-二甲基-2,5-二氢呋喃-2-酮合成路线 （共 17 条）
反应条件
1: CH3CBr2CO2Et With tert.-butyl lithium in tetrahydrofuran T=-78 - 0°C; 3.5 h; 2: 1-O-TBDPS-propan-2-one in tetrahydrofuran T=20°C; 0.5 h; 3: With hydrogenchloride in ethanol 3 h; Heating; Further stages.;
参考文献
Shindo, Mitsuru; Yoshikawa, Takashi; Itou, Yasuaki; Mori, Seiji; Nishii, Takeshi; Shishido, Kozo
Chemistry - A European Journal, 2006 , vol. 12, # 2 p. 524 - 536
反应条件
hydrogenchloride in ethanol 2.5 h; Heating;
参考文献
Shindo, Mitsuru; Yoshikawa, Takashi; Itou, Yasuaki; Mori, Seiji; Nishii, Takeshi; Shishido, Kozo
Chemistry - A European Journal, 2006 , vol. 12, # 2 p. 524 - 536
反应条件
bromine; sodium ethanolate; tert-butyl alcohol Reagens 4: Aethanol;
参考文献
Adams; Gianturco
Journal of the American Chemical Society, 1957 , vol. 79, p. 166,169
反应条件
sodium tetrahydroborate in methanol 1 h; Ambient temperature;
参考文献
Bourguignon; Schoenfelder; Schmitt; Wermuth; Hechler; Charlier; Maitre
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 893 - 897
反应条件
1: With iodine; zinc in diethyl ether Reformatsky reaction; 4 h; Inert atmosphereReflux; 2: With hydrogenchloride in diethyl ether; water T=0°C; Inert atmosphere; 3: With magnesium sulfate; toluene-4-sulfonic acid in toluene 7 h; Inert atmosphereReflux;
参考文献
Petroski, Richard J.; Bartelt, Robert J.; Vermillion, Karl
Synthetic Communications, 2009 , vol. 39, # 8 p. 1389 - 1405
反应条件
sodium hydride; 18-crown-6 ether 1.) benzene, r.t., 12 h, 2.) THF, r.t., 6 h; Yield given. Multistep reaction;
参考文献
Falsone; Wingen
Archiv der Pharmazie, 1984 , vol. 317, # 9 p. 802 - 806
反应条件
diisobutylaluminium hydride in diethyl ether; hexane
T=-20°C; 1 h; Inert atmosphere;
参考文献
Montana, Angel M.; Castellvi, Maria; Batalla, Consuelo; Grima, Pedro M.; Font-Bardia, Merce
Tetrahedron, 2012 , vol. 68, # 48 p. 9982 - 9998,17
Title/Abstract Full Text Show Details
Montana, Angel M.; Grima, Pedro M.; Castellvi, Maria; Batalla, Consuelo; Font-Bardia, Merce
Tetrahedron, 2012 , vol. 68, # 48 p. 9982 - 9998
