4-溴-5-氟-1,2-苯二胺合成路线 （共 7 条）
反应条件
hydrogen; 10Mol palladium on carbon in ethanol; dichloromethane 0.5 h;
参考文献
CalciMedica, Inc.
Patent: US2011/263612 A1, 2011 ;
Location in patent: Page/Page column 135 ;
US 20110263612 A1
反应条件
tin(ll) chloride in ethanol; ethyl acetate T=70°C; 0.583333 h;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
1: 7.2 g / H2SO4; HNO3 / H2O / 3 h / 20 °C 2: 88 percent / aq. NaOH / methanol / 2 h / 90 °C 3: 93 percent / SnCl2*2H2O / ethyl acetate; ethanol / 1 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3719 - 3742
反应条件
1: 88 percent / aq. NaOH / methanol / 2 h / 90 °C 2: 93 percent / SnCl2*2H2O / ethyl acetate; ethanol / 1 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3719 - 3742
反应条件
1: 16 h / 20 °C 2: 7.2 g / H2SO4; HNO3 / H2O / 3 h / 20 °C 3: 88 percent / aq. NaOH / methanol / 2 h / 90 °C 4: 93 percent / SnCl2*2H2O / ethyl acetate; ethanol / 1 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3719 - 3742
反应条件
1: concd. H2SO4, concd. HNO3 / 0 - 20 °C 2: concd. HCl / Heating 3: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
1: concd. HCl / Heating 2: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
