(S)-N-BOC-2,2-二甲基噁唑烷-4-羧酸甲酯合成路线 （共 5 条）
反应条件
1: With pyridinium p-toluenesulfonate in benzene 15 h; Reflux; 2: With sodium hydrogencarbonate in water; benzene
参考文献
Otsuka Chemical Co., Ltd.
Patent: EP2133335 A1, 2009 ;
Location in patent: Page/Page column 10-11 ;
EP 2133335 A1
反应条件
1: 95 percent / triethylamine / CH2Cl2 / 3.5 h / 0 - 20 °C 2: 90 percent / p-toluenesulfonic acid monohydrate / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 40, # 8 p. 805 - 810
反应条件
diisobutylaluminium hydride in toluene T=-78°C; 2.5 h;
参考文献
Qi, Xiuxiang; Wang, Xiaolai; Wang, Limin; Wang, Qiang; Cheng, Senxiang; Suo, Jishuan; Chang, Junbiao
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 805 - 810
反应条件
lithium aluminium tetrahydride in diethyl ether T=23°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Roush; Hunt
Journal of Organic Chemistry, 1995 , vol. 60, # 4 p. 798 - 806
反应条件
lithium aluminium tetrahydride in diethyl ether T=23°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Roush; Hunt
Journal of Organic Chemistry, 1995 , vol. 60, # 4 p. 798 - 806
