N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
反应条件
in methanol T=20°C; Sonication;
参考文献
Sahoo, Pathik; Sankolli, Ravish; Lee, Hee-Young; Raghavan, Srinivasa R.; Dastidar, Parthasarathi
Chemistry - A European Journal, 2012 , vol. 18, # 26 p. 8057 - 8063
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature;
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.33 h / -15 °C 2: CH2Cl2 / 1 h / -15 °C View Scheme
参考文献
Wallen, Erik A. A.; Christiaans, Johannes A. M.; Jarho, Elina M.; Forsberg, Markus M.; Venaelaeinen, Jarkko I.; Maennistoe, Pekka T.; Gynther, Jukka
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4543 - 4551
反应条件
tris(2,2,2-trifluoroethyl) borate in acetonitrile T=100°C; 24 h; Sealed tube; Overall yield = 59percent; Overall yield = 135 mg;
参考文献
Lanigan, Rachel M.; Starkov, Pavel; Sheppard, Tom D.
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4512 - 4523
反应条件
dicyclohexyl-carbodiimide in dichloromethane
参考文献
Ke, Damei; Zhan, Chuanlang; Li, Xiao; Li, Alexander D. Q.; Yao, Jiannian
Synlett, 2009 , # 9 p. 1506 - 1510
参考文献
Sakakibara; Inukai
Bulletin of the Chemical Society of Japan, 1965 , vol. 38, # 11 p. 1979 - 1984
反应条件
chloro-trimethyl-silane T=20°C; Esterification; de-tert-butoxycarbonylation; 18 h;
参考文献
Chen, Bang-Chi; Skoumbourdis, Amanda P.; Guo, Peng; Bednarz, Mark S.; Kocy, Octavian R.; Sundeen, Joseph E.; Vite, Gregory D.
Journal of Organic Chemistry, 1999 , vol. 64, # 25 p. 9294 - 9296
反应条件
thionyl chloride 2 h; Reflux;
参考文献
Oliveira, Elisabete; Capelo, Jose Luis; Lima, Joao Carlos; Lodeiro, Carlos
Amino Acids, 2012 , vol. 43, # 4 p. 1779 - 1790
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C;
参考文献
Loscher, Sebastian; Schobert, Rainer
Chemistry - A European Journal, 2013 , vol. 19, # 32 p. 10619 - 10624
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Belagali, Shiddappa L.; Mathew, Thankamma; Himaja, M.; Kocienski, Philip
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 1 p. 45 - 47
