N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C 1.2: 10 h / 60 °C 2.1: sodium hydroxide / methanol; water / 4 h / 20 °C 2.2: pH 3 View Scheme
参考文献
Ryakhovsky, Vladimir V.; Ivanov, Andrey S.
Tetrahedron, 2012 , vol. 68, # 35 p. 7070 - 7076
反应条件
1-ethyl-piperidine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide 1. 0 deg C, 2 h; 2. room temperature, 12 h;
参考文献
Kasafirek, Evzen; Fukal, Ladislav; Kas, Jan
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 12 p. 3197 - 3205
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Xiao, Youli; Lee, Kent; Liu, Pinghua
Organic Letters, 2008 , vol. 10, # 24 p. 5521 - 5524
反应条件
NMM in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
Indian Institute of Science
Patent: US2010/261871 A1, 2010 ;
反应条件
triethylamine; dicyclohexyl-carbodiimide in dichloromethane
T=0 - 20°C;
参考文献
Monney, Angele; Nastri, Flavia; Albrecht, Martin
Dalton Transactions, 2013 , vol. 42, # 16 p. 5655 - 5660
反应条件
tri-n-butyl-tin hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium(0)
1) CH2Cl2, room temp., 30 min., 2) CH2Cl2, room temp., 5 min.; Yield given. Multistep reaction;
参考文献
Roos, Eric C.; Bernabe, Pablo; Hiemstra, Henk; Speckamp, W. Nico
Tetrahedron Letters, 1991 , vol. 32, # 45 p. 6633 - 6636
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in acetonitrile
2 h;
参考文献
Nguyen, Dung Le; Dormoy, Jean-Robert; Castro, Bertrand; Prevot, Daniel
Tetrahedron, 1981 , vol. 37, # 24 p. 4229 - 4238
反应条件
1: dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 20 °C
2: triethylamine / tetrahydrofuran / 20 °C
View Scheme
参考文献
Nowshuddin, Shaik; Ram Reddy
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 22 - 25
反应条件
1: Et3N / tetrahydrofuran / 0.33 h / -10 °C
2: diethyl ether; tetrahydrofuran / 18 h / 20 °C
3: 96 percent / silver benzoate; Et3N / 18 h / 20 °C
View Scheme
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
反应条件
1: dicyclohexylcarbodiimide (DCC) / acetonitrile; dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 4 h
2: acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Zemlyakov
Chemistry of Natural Compounds, 1998 , vol. 34, # 1 p. 78 - 79
