N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
反应条件
1: 94.3 percent / N,N'-dicyclohexylcarbodiimide / CHCl3
2: 47.5 percent / tetrahydrofuran / 4 h
View Scheme
参考文献
Zhou, Zheng Hong; Tang, Yi Long; Li, Kang Ying; Liu, Bing; Tang, Chu Chi
Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 603 - 606
反应条件
4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate in dichloromethane
2 h;
参考文献
Moulin, Aline; Martinez, Jean; Fehrentz, Jean-Alain
Tetrahedron Letters, 2006 , vol. 47, # 43 p. 7591 - 7594
反应条件
1: 94 percent / BOP; N-methylmorpholine / CH2Cl2 / 2 h
2: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 2 h / 80 °C
View Scheme
参考文献
Moulin, Aline; Martinez, Jean; Fehrentz, Jean-Alain
Tetrahedron Letters, 2006 , vol. 47, # 43 p. 7591 - 7594
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Okada; Tsuda; Mu; Hirano; Okamoto; Kakegawa; Matsumoto; Sato
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 1 p. 96 - 99
反应条件
1: 92 percent / 4-dimethylaminopyridine, N,N'-dicyclohexylcarbodiimide / dioxane; CH2Cl2 / a) 0 deg C, 1 h, b) RT, 12 h
2: 96 percent / H2 / 10 percent Pd/C / ethanol; diethyl ether / Ambient temperature
3: 88 percent / 3-morpholino-1-propanesulfonate, CaCl2 (pH 8.0) / dimethylsulfoxide / 12 h / 25 °C / trypsin
View Scheme
参考文献
Sekizaki, Haruo; Itoh, Kunihiko; Toyota, Eiko; Tanizawa, Kazutaka
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 5 p. 846 - 849
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 12 p. 5301 - 5309
参考文献
Buckley, Thomas F.; Rapoport, Henry
Journal of the American Chemical Society, 1981 , vol. 103, # 20 p. 6157 - 6163
反应条件
4-(N,N-dimethlyamino)pyridine in tert-butyl alcohol
T=20°C; 12 h;
参考文献
Strazzolini, Paolo; Melloni, Tiziana; Giumanini, Angelo G
Tetrahedron, 2001 , vol. 57, # 43 p. 9033 - 9043
反应条件
4-(N,N-dimethlyamino)pyridine; TEA
T=35°C; 0.5 h;
参考文献
Zeggaf, Choukri; Poncet, Joel; Jouin, Patrick; Dufour, Marie-Noelle; Castro, Bertrand
Tetrahedron, 1989 , vol. 45, # 16 p. 5039 - 5050
反应条件
1: C16H22NO4PolS With 3-methyl-phenol; trifluoroacetic acid
0.25 h; Automated synthesizersolid phase reaction;
2: N-tert-butoxycarbonyl-O-benzyl-L-serine With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; diisopropyl-carbodiimide
1 h; Automated synthesizersolid phase reaction;
3: BOC-glycine; N-tert-butoxycarbonyl-L-alanine; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-L-threonine benzyl ether; BOC-S-4-methoxybenzyl-L-cysteine; N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-L-lysine; N-BOC-D-tryptophan; Boc-Asn(Xan)-OH Further stages;
参考文献
Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E.; Reubi, Jean Claude
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 5981 - 5987
