N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
反应条件
1: C16H22NO4PolS With 3-methyl-phenol; trifluoroacetic acid 0.25 h; Automated synthesizersolid phase reaction; 2: N-tert-butoxycarbonyl-O-benzyl-L-serine With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; diisopropyl-carbodiimide 1 h; Automated synthesizersolid phase reaction; 3: BOC-glycine; N-tert-butoxycarbonyl-L-alanine; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-L-threonine benzyl ether; BOC-S-4-methoxybenzyl-L-cysteine; N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-L-lysine; N-(tert-butoxycarbonyl)-L-tryptophan; Boc-Asn(Xan)-OH Further stages;
参考文献
Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E.; Reubi, Jean Claude
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 5981 - 5987
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane Ambient temperature;
参考文献
Laakso; Stjarnkvist; Sjoholm
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 2 p. 134 - 140
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Societe Nationale des Poudres et Explosifs
Patent: US4782164 A1, 1988 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664
参考文献
Pastuszak, Jacek; Gardner, Joseph H.; Singh, Jasbir; Rich, Daniel H.
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2982 - 2987
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
反应条件
1: 88.2 percent / HOBt; EDCI / dimethylformamide / 20 °C 2: 93.7 percent / aq. NaOH / methanol / 2 h / 20 °C View Scheme
参考文献
International Journal of Chemical Kinetics, , vol. 38, # 6 p. 376 - 385
反应条件
4-methyl-morpholine in chloroform; ethyl acetate
参考文献
US4432971 A1, ;
US 4432971 A
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 14 p. 3635 - 3638
反应条件
1: DCC / CH2Cl2 2: LiAlH4 / tetrahydrofuran 3: CH2Cl2 4: LiOH / methanol; H2O View Scheme
参考文献
Conroy, Trent; Guo, Jin T.; Linington, Roger G.; Hunt, Nicholas H.; Payne, Richard J.
Chemistry - A European Journal, 2011 , vol. 17, # 48 p. 13544 - 13552
