N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
参考文献
WiSys Technology Foundation
Patent: US2010/261711 A1, 2010 ;
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C; 2: With hydrogenchloride in methanol; diethyl ether T=50°C; 0.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/127587 A1, 2006 ;
Location in patent: Page/Page column 103-104 ;
WO 2006/127587 A1
反应条件
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1) THF, -20 deg C, 10 min; 2) THF, -15 deg C, 2 h, rt, overnight 2: 88 percent / P4S10, Na2CO3 / tetrahydrofuran / 1) 0 deg C, 30 min, 2.) rt, 2.5 h 3: 79 percent / NaNO2 / acetic acid; H2O / 0.5 h / 0 °C View Scheme
参考文献
Ashraf Shalaby; Grote, Christopher W.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9045 - 9048
反应条件
1.1: isobutyl chloroformate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -10 °C 1.2: 0.08 h / -10 °C / |Inert atmosphere 2.1: p-toluenesulfonyl chloride; potassium hydroxide / diethyl ether / |Reflux; |Inert atmosphere View Scheme
参考文献
Rotstein, Benjamin H.; Yudin, Andrei K.
Synthesis (Germany), 2012 , vol. 44, # 18 p. 2851 - 2858
反应条件
1: in tetrahydrofuran T=20°C; 0.5 h; 2: With hydrazine hydrate in tetrahydrofuran T=20°C; Title compound not separated from byproducts;
参考文献
Bondebjerg, Jon; Fuglsang, Henrik; Valeur, Kirsten Rosendal; Kaznelson, Dorte Wissing; Hansen, Johnny Arnsdorf; Pedersen, Rene Orup; Krogh, Berit Olsen; Jensen, Bo Skaaning; Lauritzen, Conni; Petersen, Gitte; Pedersen, John; Naerum, Lars
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 14 p. 4408 - 4424
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=0 - 20°C; 8.5 h;
参考文献
WISYS TECHNOLOGY FOUNDATION, INC.
Patent: US2006/3995 A1, 2006 ;
Location in patent: Page/Page column 60-61 ;
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=0 - 20°C; 8.5 h;
参考文献
WISYS TECHNOLOGY FOUNDATION, INC.
Patent: US2006/3995 A1, 2006 ;
Location in patent: Page/Page column 56-57 ;
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=0 - 20°C; 8.5 h;
参考文献
WISYS TECHNOLOGY FOUNDATION, INC.
Patent: US2006/3995 A1, 2006 ;
Location in patent: Page/Page column 58-59 ;
反应条件
water T=170°C; 0.05 h; Microwave irradiation;
参考文献
Wang, Gan; Li, Chunju; Li, Jian; Jia, Xueshun
Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1438 - 1440
反应条件
hydrogenchloride; dicyclohexyl-carbodiimide 1.) CH2Cl2 2.) CH2Cl2, RT, overnight; Multistep reaction;
参考文献
Smith, Grant Gill; Baum, Rocky
Journal of Organic Chemistry, 1987 , vol. 52, # 11 p. 2248 - 2255
