1.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 0 - 10 °C 1.2: 0 °C 2.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 3.1: ammonia / water; methanol / 10 °C 4.1: N-bromosuccinmide / dichloromethane / 3 h / -10 °C View Scheme
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; LAST, Stefaan Julien; HOUPIS, Ioannis Nicolaos; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2011/54834 A1, 2011 ;
1: 1-(tert-butoxycarbonyl)-L-proline With pyridine; 4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate in tetrahydrofuran T=0°C; 2: diazomethane in tetrahydrofuran; diethyl ether T=0°C; 0.5 h;
参考文献
Vasanthakumar, Ganga-Ramu; Patil, Basanagoud S.; Suresh Babu, Vommina V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 18 p. 2087 - 2089
