1: With 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in tetrahydrofuran
T=20°C; 18 h;
2: With THF*DH3 in tetrahydrofuran
T=20°C; 18 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2004/92170 A2, 2004 ;
Location in patent: Page 32; 33 ;
WO 2004/092170 A2