5-苯基-1H-嘧啶-2,4-二酮合成路线 （共 15 条）
反应条件
hydrogenchloride in water T=100°C; 24 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/37814 A1, 2004 ;
Location in patent: Page 180-181 ;
WO 2004/037814 A1
反应条件
trifluorormethanesulfonic acid; trifluoroacetic acid T=0°C; 2 h;
参考文献
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNIVERSITA' DEGLI STUDI DI PARMA; PIOMELLI, Daniele; REALINI, Natalia; MOR, Marco; PAGLIUCA, Chiara; PIZZIRANI, Daniela; SCARPELLI, Rita; BANDIERA, Tiziano
Patent: WO2013/178576 A1, 2013 ;
Location in patent: Page/Page column 72; 73 ;
反应条件
palladium 10 on activated carbon; ammonium formate in methanol T=72°C; 17 h;
参考文献
Cernova, Miroslava; Cerna, Igor; Pohl, Radek; Hocek, Michal
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5309 - 5319
反应条件
1: T=130°C; 2: With sodium in ethanol T=80°C; Further stages.;
参考文献
Morshed, M. Monzur; Wang, Qinwei; Islam, Shahidul; Hossain, M. Mahmun
Synthetic Communications, 2007 , vol. 37, # 23 p. 4173 - 4181
反应条件
Na2[PdCl4]; potassium hydroxide in water T=100 - 200°C; 0.666667 h; Inert atmosphereMicrowave irradiation;
参考文献
Gallagher-Duval, Shawn; Herve, Gwenaelle; Sartori, Guillaume; Enderlin, Gerald; Len, Christophe
New Journal of Chemistry, 2013 , vol. 37, # 7 p. 1989 - 1995
反应条件
palladium diacetate; sodium carbonate in various solvent(s) Suzuki reaction; 0.2 h; microwave irradiation;
参考文献
Villemin, Didier; Gomez-Escalonilla, Maria Jose; Saint-Clair, Jean-Francois
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 635 - 637
反应条件
dilithium tetrachloropalladate 1.) MeOH, RT, 1 h, 2.) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Bigge, Christopher F.; Mertes, Mathias P.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 1994 - 1997
参考文献
Synthetic Communications, , vol. 37, # 23 p. 4173 - 4181
参考文献
Journal of the American Pharmaceutical Association (1912-1977), , vol. 44, p. 545,547
反应条件
sodium hydroxide; urea
参考文献
Journal of the Chemical Society, , p. 347 Anm.
