N-Boc-2-哌啶甲醇合成路线 （共 13 条）
反应条件
1: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 2: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
1: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 2: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT 3: 70 percent / KMnO4, MgSO4 / acetone / 0.5 h / Ambient temperature View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C
1.2: 20 h / 20 °C
2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 h / 25 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; HAMMOND, Marlys; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne; SARPONG, Martha, A.; SEEFELD, Mark, Andrew
Patent: WO2011/149827 A1, 2011 ;
