4,4A,5,6,7,8-六氢-4,4A-二甲基-6-(1-甲基亚乙基)-(4R-顺)-2(3H)-萘酮合成路线 （共 19 条）
反应条件
1: 71 percent / NaNH2 / benzene 2: 1.) O3; 2.) Zn/CH3COOH / 1.) -78 deg C, 30 min; 2.) room temperature overnight. 3: 73 percent / HCl / acetic acid / 21 h / Ambient temperature 4: 81 percent / SiO2 / CHCl3 / 27 h / 60 °C View Scheme
参考文献
Yanami, Tetsuji; Miyashita, Masaaki; Yoshikoshi, Akira
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 607 - 612
反应条件
1: 1.) mercuric acetate; 2.) LiCl, PdCl2, CuCl2. / 1.) room temperature, CH3OH, 15 min; 2.) 55 deg C, CH3OH, 1 hour. 2: 73 percent / HCl / acetic acid / 21 h / Ambient temperature 3: 81 percent / SiO2 / CHCl3 / 27 h / 60 °C View Scheme
参考文献
Yanami, Tetsuji; Miyashita, Masaaki; Yoshikoshi, Akira
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 607 - 612
反应条件
1: 1.) O3; 2.) Zn/CH3COOH / 1.) -78 deg C, 30 min; 2.) room temperature overnight. 2: 73 percent / HCl / acetic acid / 21 h / Ambient temperature 3: 81 percent / SiO2 / CHCl3 / 27 h / 60 °C View Scheme
参考文献
Yanami, Tetsuji; Miyashita, Masaaki; Yoshikoshi, Akira
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 607 - 612
反应条件
1.1: 63 percent / AcONa; Ac2O / 3 h / Heating 2.1: n-BuLi / hexane; tetrahydrofuran / 0.08 h / -78 °C 2.2: 0.115 g / tetrahydrofuran; hexane / 3 h / -78 - -20 °C View Scheme
参考文献
Revial, Gilbert; Jabin, Ivan; Pfau, Michel
Tetrahedron Asymmetry, 2000 , vol. 11, # 24 p. 4975 - 4983
20489-45-62-[(2R,8R,8aS)-8,8A-二甲基-1,2,3,4,6,7,8,8A-八氢-2-萘基]-2-丙醇
→
反应条件
1: (tBuO)2CrO2, Ac2O / acetic acid; CCl4 2: POCl3, Py View Scheme
参考文献
Hikino; Suzuki; Takemoto
Chemical and pharmaceutical bulletin, 1968 , vol. 16, # 5 p. 832 - 838
反应条件
toluene-4-sulfonic acid in chloroform
参考文献
van der Gen,A. et al.
Recueil des Travaux Chimiques des Pays-Bas, 1971 , vol. 90, p. 1045 - 1054
反应条件
pyridine; trichlorophosphate
参考文献
Hikino; Suzuki; Takemoto
Chemical and pharmaceutical bulletin, 1968 , vol. 16, # 5 p. 832 - 838
反应条件
selenium
T=260 - 330°C;
参考文献
Naves; Perrottet
Helvetica Chimica Acta, 1941 , vol. 24, p. 3,21
参考文献
Naves; Perrottet
Helvetica Chimica Acta, 1941 , vol. 24, p. 3,21
